Description

Arthropen Vet 250 Injection is a sterile solution formulated as an aid in the treatment of non-infectious inflammatory joint
disease in horses. Where to Buy Arthropen Pentosan Vet 250 injection for sale online Australia

Pharmacology

Pentosan polysulfate (PPS) is a semi-synthetic polysaccharide with a linear xylan (pentosan) backbone. Xylan is a hemicellulose
derived from plant origin by extraction from the cell walls of hardwoods. PPS possesses antiinflammatory, anti-arthritic and
chondroprotective activities. The beneficial effects of pentosan polysulfate in joint disease are due to the following actions:
a) Anti-inflammatory activity.
b) Inhibition of neutrophil migration into the joint.
c) Stimulation of hyaluronic acid synthesis by synovial fibroblasts, resulting in increased volume and viscosity of synovial fluid.
d) Stimulation of proteoglycan synthesis by chondrocytes.
e) Fibrinolytic activity, resulting in improved circulation to subchondral bone and peri-articular structures. Where to Buy Arthropen Pentosan Vet 250 injection for sale online Australia

Clinical Application

Arthropen Vet 250 Injection is indicated as an aid in the treatment of non-infectious, inflammatory joint disease in the horse. Clinical
applications include the following conditions: osteoarthritis, osteochondritis dissecans (OCD), traumatic joint and peri-articular
inflammation. If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.

Precautions

Due to the anti-coagulant properties of PPS, bleeding from local blood vessels following intraarticular administration is more likely
if PPS is left in contact with the tissue along the injection track. The following steps are recommended for intra-articular injection
of Arthropen Vet 250 Injection:
(i) Prepare site as for surgery, avoiding iodinebased skin preparations. Use a neutral, soapless skin cleanser.
(ii) A 20 gauge non-cutting needle is suitable for injection. Introduce into the joint space with steady even pressure.
(iii) Allow approximately 1 mL of synovial fluid to escape before attaching the syringe containing Arthropen Vet 250
Injection. Withdraw synovial fluid into the syringe if possible before injecting into the joint.
(iv) Draw back on the syringe once or twice to mix Arthropen Vet 250 Injection with synovial fluid.
(v) Apply a firm elastic bandage around the joint for 3 to 4 hours after injection and keep the horse in a confined space during
this time. Careful technique, avoiding tissue damage, and firm postinjection bandaging will minimise the risk of intraarticular haemorrhage, which is the most common cause of acute inflammatory swelling following intra-articular injection. Where to Buy Arthropen Pentosan Vet 250 injection for sale online Australia

Dosage and Administration

Use contents within 28 days of first broaching of the vial. Discard the unused portion.
Dose Rate
Intra-muscular: 3 mg/kg (6 mL/500 kg horse) intramuscular on four occasions with an interval of 5-7 days between injections.
Intra-articular: 1 mL by intra-articular injection. May be repeated at weekly intervals for 3 to 4 treatments. More than one joint may
be treated at the one time. The horse should be rested for 2 weeks after the final injection, followed by a further 2 weeks of graded
walking exercise before returning to work.
Meat Withholding Period (Horses): DO NOT USE less than 28 days before slaughter for human consumption.
First Aid: If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131126 or in New Zealand 0800
764 766.
Disposal: Dispose of empty container and outer packaging by wrapping with paper and putting in garbage. Discarded needles/
sharps should immediately be placed in a designated and appropriately labelled “sharps” container.
Storage: Store between 2 and 8oC (Refrigerate. Do not freeze). Protect from light. Store vials in an upright position. Where to Buy Arthropen Pentosan Vet 250 injection for sale online Australia